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Madhukar Patil, Abhijeet
- A Study of Maternal and Fetal Outcome of Thrombocytopenia in Pregnancy
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PDF Views:86
Authors
Affiliations
1 Associate Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
2 Former PG Resident, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
3 Professor and Head, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
4 Assistant Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
1 Associate Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
2 Former PG Resident, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
3 Professor and Head, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
4 Assistant Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, IN
Source
MVP Journal of Medical Sciences, Vol 8, No 1 (2021), Pagination: 16–22Abstract
Background: Thrombocytopenia is found to complicate pregnancies in India. The major function of platelets is the initiation of haemostasis. Thrombocytopenia can result in spontaneous bleeding from any part of the body. It may be associated with serious bleeding at delivery and may require emergent maternal and neonatal care. Introduction: After anaemia, thrombocytopenia is the most frequently occurring hematologic disorder in pregnancy. It is found to complicate 7% to 8% of pregnancies in India. The major function of platelets is the initiation of haemostasis, and hence, thrombocytopenia can result in spontaneous bleeding from any part of the body. It may be associated with serious bleeding at delivery and may require emergent maternal and neonatal care. Thrombocytopenia is diagnosed if the platelet count 150 × 109/l, caused by increased platelet lysis or reduced inefficient production. Aims & Objectives: To study the maternal and fetal outcome of thrombocytopenia in pregnancy and to study some of the causes of thrombocytopenia in pregnancy. Methodology: Total 113 cases with maternal thrombocytopenia were included in present study after satisfying inclusion and exclusion criteria and followed till delivery. We studied maternal complications gestational age at delivery, indication of induction of labour and method (if required) and mode of delivery, NICU stay were recorded. Results: Majority of the patients i.e. 63 patients (55.8%) were in the age group of 20-25 years. Among 113 cases; primigravida (56 cases, 49.6%) and multigravida (57 cases, 50.4%) were almost equally distributed. Majority of the study population was diagnosed with Gestational thrombocytopenia 50.4% followed by severe pre-eclampsia 22.12%, HELLP syndrome 8.8%, abruption 5.3% antepartum eclampsia and dengue 2.7% each. Maternal mortality was seen in 2 cases (1.8%). Mean birth weight was found to be 2.45 Kgs. of 113 babies, neonatal mortality was seen in 15 cases, NICU admission was indicated in 18 babies and KMC care was needed for 1 baby. Conclusion: The most common cause of thrombocytopenia during pregnancy is Gestational Thrombocytopenia (GT) followed by pre-eclampsia, eclampsia and HELLP syndrome. With platelet counts above 70,000/ μLno prior history of thrombocytopenia the condition is more likely to be GT. The lack of well-defined symptomatology and clinical presentation makes early and accurate diagnosis difficult leading to delay in treatment.Keywords
Gestational Thrombocytopenia, HELLP Syndrome, Pre-EclampsiaReferences
- Richard F, Alexander H. Thrombocytopenia in pregnancy. 2006. Accessed on 15 Nov 2020. www.emedicine.medscape. com/article.
- Dwivedi P, Puri M, Nigam A, Agarwal K. Fetomaternal outcome in pregnancy with severe thrombocytopenia. Eur Rev Med Pharmacol Sci. 2012; 16(11): 1563-1566.
- Perepu U, Rosenstein L. Maternal thrombocytopenia in pregnancy. Proceedings Obstetrics Gynecol. 2013; 3(1): 6. https://doi.org/10.17077/2154-4751.1193.
- James D, Steer P, Weiner C, Gonik B, Crowther C, Robson S. High Risk Pregnancy: Management Options. 4th Ed. Elsevier Health Sciences; 2011.
- Arias F, Bhide AG, Arulkumaran S, Damania K, Dafarty SN. Parctical Guide to High Risk Pregnancy and Delivery. 4th ed. Chennai: Elsevier Health Sciences APAC; 2014.
- Sainio S, Kekomäki R, Riikonon S, Teramo K. Maternal thrombocytopenia at term: A population-based study. Acta Obstet Gynecol Scand. 2000; 79(9): 744-749. https://doi. org/10.1034/j.1600-0412.2000.079009744.x, https://doi. org/10.3109/00016340009169188.
- Boehlen F, Hohlfeld P, Extermann P, Perneger TV, de Moerloose P. Platelet count at term pregnancy: A reappraisal of the threshold. Obstet Gynecol. 2000; 95(1): 29-33. https://doi.org/10.1016/S0029-7844(99)00537- 2, https://doi.org/10.1097/00006250-200001000-00006. PMid:10636497.
- McCrae KR. Thrombocytopenia in pregnancy: Differential diagnosis, pathogenesis, and management. BloodRev. 2003; 17(1): 7-14. https://doi.org/10.1016/S0268- 960X(02)00056-5.
- Ballem PJ. Hematological problems of pregnancy. Can Fam Physician. 1988; 34: 2531-2537.
- Gernsheimer T, James AH, Stasi R. How I treat thrombocytopenia in pregnancy. Blood. 2013; 121(1): 38-47. https:// doi.org/10.1182/blood-2012-08-448944. PMid:23149846.
- Asrie F, Enawgaw B, Getaneh Z. Prevalence of thrombocytopenia among pregnant women attending antenatal care service at Gondar University Teaching Hospital in 2014, Northwest Ethiopia. J Blood Med. 2017; 8: 61-66. https://doi.org/10.2147/JBM.S136152. PMid:28670146 PMCid:PMC5479266.
- Zutshi V, Gupta N, Arora R, Dhanker S. Prevalence of gestational thrombocytopenia and its effect on maternal and fetal outcome. Iraqi J Hematol. 2019; 8: 21-24. https://doi. org/10.4103/ijh.ijh_17_18.
- Vyas R, Shah S, Yadav P, Patel U. Comparative study of mild versus moderate to severe thrombocytopenia in third trimester of pregnancy in a tertiary care hospital. NHL J Med Sci. 2014; 3: 8-11.
- Mohseni M, Asgarlou Z, Azami Aghdash S, Gareh Sheyklo S, Tavananezhad N, Moosavi A. The global prevalence of thrombocytopenia among pregnant women: A systematic review and meta analysis. Nurs Midwifery Stud. 2019; 8: 57-63.
- Wang X, Xu Y, Luo W, Feng H, Luo Y, Wang Y, Liao H. Thrombocytopenia in pregnancy with different diagnoses: Differential clinical features, treatments, and outcomes. Medicine (Baltimore). 2017; 96(29): e7561. https://doi. org/10.1097/MD.0000000000007561. PMid:28723784 PMCid:PMC5521924.
- Parnas M, Sheiner E, Shoham-Vardi I, Burstein E, Yermiahu T, Levi I, et al. Moderate to severe thrombocytopenia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2006; 128(1- 2): 163-168. https://doi.org/10.1016/j.ejogrb.2005.12.031. PMid:16533554.
- Anita H, Reddy A, Vanaja S, Anupama H. Thrombocytopenia in Pregnancy. 2016; 3(1): 7-12. https:// doi.org/10.5958/2394-2754.2016.00002.3.
- Arora M, Goyal L, Khutan H. Prevalence of Thrombocytopenia during pregnancy and its effect on pregnancy and neonatal outcome. 2017; (3): 3-5. https:// doi.org/10.21276/aimdr.2017.3.2.ME2.
- Ajzenberg N, Dreyfus M, Kaplan C, Yvart J, Weill B, Tchernia G. Pregnancy- associated Thrombocytopenia revisited: Assessment and follow-up of 50 cases. Blood. 1998; 92(12): 4573-4580. https://doi.org/10.1182/blood. V92.12.4573.424k25_4573_4580, https://doi.org/10.1182/ blood.V92.12.4573. PMid:9845523.
- Clinical Study of Prevalence of Polycystic Ovarian Syndrome in Adolescent Girls with Irregular Menstruation
Abstract Views :129 |
PDF Views:93
Authors
Affiliations
1 Former PG Resident, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
2 Professor and Head, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
3 Associate Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
1 Former PG Resident, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
2 Professor and Head, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
3 Associate Professor, Department of Obstetrics and Gynaecology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, IN
Source
MVP Journal of Medical Sciences, Vol 8, No 1 (2021), Pagination: 46-53Abstract
Background: Polycystic Ovarian Syndrome (PCOS) accounts for significant healthcare costs, emotional distress and significant impact on quality of life of women. Even though a fairly common problem it is a complex trait with unclear etiology. The present study was conducted to study various clinical presentations in the adolescent girls with polycystic ovarian syndrome having menstrual irregularities. Aims and Objectives: To study the anthropometric measurements among PCOS patients and to find the association of various risk factors. Material and Methods: It was an observational, cross-sectional study conducted in Out-patient department of Obstetrics and Gynecology at a tertiary healthcare center in Maharashtra. This study was conducted amongst the adolescent girls coming to the OPD of Obstetrics and Gynecology with irregular menses. Results: We evaluated the study subjects according to the Rotterdam’s criteria. We observed that 51.96% cases fulfilled two of the three criteria, while 29.13% cases fulfilled all the three criteria from Rotterdam’s criteria for PCOS. Oligomenorrhea was noted among 46.45% subjects, followed by hypomenorrhea among 32.28% cases. Primary amenorrhea was observed among 21.25% cases. Secondary amenorrhea was seen as the presenting symptom in 4.72% cases. Conclusions: Adolescents who had irregular menses and signs of increased androgen secretion should undergo investigations and must be treated. Prompt treatment following early diagnosis of PCOS helps improve quality of life in young adolescent girls.Keywords
Menstrual Irregularities, Rotterdam’s Criteria, Modified Ferriman-Gallwey Score, PCOSReferences
- Insler V, Lunesfeld B. Polycystic ovarian disease: A challenge and controversy. Gynecol Endocrinol. 1990; 4: 51–69. https://doi.org/10.3109/09513599009030691. PMid:2186596
- Chereau A. Memoires pour Servir al’Etude des Maladies des Ovaries. aris: Fortin, Masson & Cie; 1844.
- Rokitansky C. A manual of pathological anatomy - Vol II. Philadelphia: Blanchard & Lea; 1855. p. 246.
- Bulius G, Kretschmar C. Angiodystrophia. Stuttgart: Verlag von Ferdinand Enke; 1897.
- Tait L. Removal of normal ovaries. Br Med J. 1879; 813: 284.
- Stein IF, Leventhal ML. Amenorrhoea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935; 29: 181–91. https://doi.org/10.1016/S0002-9378(15)30642-6
- Gupta M, Singh D, Toppo M, Priya A, Sethia S, Gupta P. A cross sectional study of polycystic ovarian syndrome among young women in Bhopal, Central India. Int J Community Med. 2018; 5(1): 95-100. https://doi.org/10.18203/2394- 6040.ijcmph20175603
- Chhabra S, Gautam RK, Kulshreshtha B, Prasad A, Sharma N. Hirsutism: A clinico-investigative study. Int J Trichology. 2012; 4(4): 246–50. https://doi.org/10.4103/0974- 7753.111204. PMid:23766607. PMCid:PMC3681104
- Yildiz BO, Knochenhauer ES, Azziz R. Impact of obesity on the risk for polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 Jan; 93(1): 162–8. https://doi.org/10.1210/ jc.2007-1834. PMid:17925334. PMCid:PMC2190739
- Majumdar A, Singh TA. Comparison of clinical features and health manifestations in lean vs. obese Indian women with polycystic ovarian syndrome. J Hum Reprod Sci. 2009; 2: 12–7. https://doi.org/10.4103/0974-1208.51336. PMid:19562068. PMCid:PMC2700686
- Snehalatha C, Ramchandran A, Kapur A, Vijay V. Agespecific prevalence and risk associations for impaired glucose tolerance in urban southern Indian population. J Assoc Physicians India. 2003; 51: 766–9.
- Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: Aprospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999; 84: 165–9. https:// doi.org/10.1210/jcem.84.1.5393. PMid:9920077
- Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999; 22: 141–6. https://doi.org/10.2337/ diacare.22.1.141. PMid:10333916